Welcome to HiU-P-DDS

Hiroshima University Research Center for

Photo-Drug-Delivery Systems

Manabu Abe (Organic Photochemistry),

Noboru Hattori (Medical Science), Taku Nakashima (Medical Science)

Shoji Ishizaka (Analytical Chemistry), Hidenori Aizawa (Medical Science)

Tatsuo Nehira (Biological Chemistry), Norimitsu Morioka (Pharmacy),

Kazue Nakashima (Pharmacy), Rui Watanabe (Chemical Industry)

Caged compounds (see, In Dynamic Studies in Biology, Goeldner, M.; Givens, R. Eds., Wiley-VCH, 2005.), which temporally inactivate bioactive compounds using photo-labile protecting groups (PPGs, see Klán et al. Chem. Rev. 2013, 113, 119), are physiologically useful, because the bioactive compounds may be spatiotemporally released (=uncaged) upon photolysis to investigate the mechanism of bioactivity in living tissues. Highly efficient uncaging and appropriate water solubility are the crucial factors for the practical use in vivo studies. In addition to the fundamental factors, the near IR (NIR) excitation of caged molecules using 650-1050 nm renders deeper investigation of the role of bioactive substances, because the light can reach the deeper site of tissues, see Ellis-Davies et al. Nat. Methods, 2006, 3, 35. The two-photon (TP) excitation technique using NIR light realizes a highly spatiotemporal control of the release of bioactive molecules. In this research center, design, synthesis, and physiological application of TP-responsive molecules are investigated for our future science.

See, Abe, M. et al., Synthesis, 2017, 49(15), 3337-3346.

International Symposium on Caged Compounds (March 9-10, 2018)

at Hiroshima International Conference Center

https://www.pcf.city.hiroshima.jp/icch/index.html

Supported by HiU-P-DDS

Hiroshima University Research Center for Photo-drug-delivery systems

March 9th (Friday), 2018

*45-50 min (talk) + 10-15 min (discussion)

9:30-9:40

Dr. Manabu Abe (Hiroshima, Japan)

Opening

9:40-10:40

Dr. Graham Ellis-Davies (New York, USA)

"Chemistry and biology with caged compounds"

10:40-11:40

Dr. Alexander Heckel (Frankfurt, Germany)

"Regulation of nucleic acids in time and space"

11:40-12:40

Dr. Toshiaki Furuta (Funabashi, Japan)

"Targeting of caged compounds to cells of interest"

14:00-15:00

Dr. Hidehiko Nakagawa (Nagoya, Japan)

"Photo-controllable NO releasers and induction of biological responses"

15:00-16:00

Dr. Peter Dalko (Paris, France)

"Light sensitive probes: extending the activation window"

16:15-17:45

Poster session

March 10th (Saturday), 2018

9:30-10:30

Dr. Rich Givens (Kansas, USA)

"New horizons for caged compounds: the importance of photorelease mechanisms

10:30-11:30

Dr. Petr Klán (Brno, Czech)

"Transition-metal-free releasing compounds activatable by visible to NIR light"

11:30-12:00

Dr. Manabu Abe (Hiroshima, Japan)

"Design and synthesis of NIR two-photon responsive chromophores"

List of Publications.

Design and Synthesis of Two-Photon Responsive Chromophores for Near-Infrared Light Induced Uncaging Reactions

Manabu Abe,* Youhei Chitose, Satish Jakkampudi, Pham Thi Thu Thuy, Lin Qianghua, Bui Thi Van, Ayato Yamada, Ryoko Oyama, Miyu Sasaki, and Claudine Katan*

SYNTHESIS, 2017, 49(15), 3337-3346.

Special Issue for Herbert Mayr's 70th Birthday

Design and Synthesis of a Caged Carboxylic Acid with a Donor-π-Donor Coumarin Structure: One-photon and Two-photon Uncaging Reactions Using Visible and Near-Infrared Lights

Chitose, Youhei; *Abe, Manabu; Furukawa, Ko; Lin, Jhe-Yi; *Lin, Tzu-Chau; *Katan, Claudine

Organic Letters, 2017, 19(10), 2622-2625.

Suplatast tosilate protects the lung against hyperoxic lung injury by scavenging hydroxyl radicals

Kazuhide Fukuhara, Taku Nakashima; Manabu Abe; Takeshi Masuda; Hironobu Hamada; Hiroshi Iwamoto; Kazunori Fujitaka; Nobuoki Kohno; Noboru Hattori*

Free Radical Biology & Medicine, 2017, 106, 1-9.

Design and Synthesis of a 4-Nitrobromobenzene Derivative bearing an Ethylene Glycol Tetraacetic acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region, and Their Application In Vivo

Jakkampudi, Satish; *Abe, Manabu; Komori, Naomitsu; Takagi, Ryukichi; Furukawa, Ko; Katan, Claudine; Sawada, Wakako; Takahashi, Noriko; *Kasai, Haruo

in ACS Omega,2016, 1(2), 193-201, Open Access Paper

Design, Synthesis, and Reaction of π-Extended Coumarin-Based New Caged Compounds with Two-Photon Absorption Character in the Near-IR Region

By Chitose, Youhei; *Abe, Manabu; Furukawa, Kou; Katan, Claudine

Chemistry Letters, 2016, 45(10), 1186-1188.

Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light

By Naomitsu Komori, Satish Jakkampudi, Ryusei Motoishi, Manabu Abe*, Kenji Kamada,* Ko Furukawa, Claudine Katan*, Wakako Sawada, Noriko Takahashi, Haruo Kasai, Bing Xue, and Takayoshi Kobayashi

Chem. Commun., 2016, 52(2), 331-334, DOI: 10.1039/C5CC07664A, Open Access Paper

Caged Glutamates with π-Extended 1,2-Dihydronaphthalene Chromophore: Design, Synthesis, Two-Photon Absorption Property, and Photochemical Reactivity. Boinapally, Srikanth; Huang, Bo; Abe, Manabu*; Katan, Claudine*; Noguchi, Megumi; Watanabe, Satoshi; Kasai, Haruo; Xue, Bing; Kobayashi, Takayoshi.

J. Org. Chem., 2014, 79, 7822-7830. As a Featured Article. DOI: 10.1021/jo501425pl.

Synthesis and photochemical reactivity of caged glutamates with a <pi>-extended coumarin chromophore as a photolabile protecting group

Sakamoto, Y.; Boinapally, S.; Katan, C.; Abe, M.*

Tetrahedron Lett., 2013, 54 (52), 7171-7174. 10.1016/j.tetlet.2013.10.107